Trimethoprim drug derivatives: A review of synthesis, metal complexes, ‎nanoparticles, and biological activity

Articles in Press

Document Type : Review Article

Authors

1 Sinai university, Suez canal university,

2 Chemistry department, Faculty of Science, Suez Canal University, Ismailia, Egypt

3 Chemistry, Faculty of science, Suez Canal

Abstract

Trimethoprim is currently often utilized in modern medicine due to its organic features. ‎‎Trimethoprim inhibits vulnerable organisms from converting dihydrofolate to ‎tetrahydrofolate, which is the active form of Folic acid.‎ We report on many Trimethoprim ‎derivatives and their complexes were characterized using various spectroscopic techniques, ‎including X-ray diffraction, infrared, and ultraviolet-visible measurements.‎ In this review, ‎the pharmacological properties and molecular mechanism of TMP in recent years are ‎discussed. Trimethoprim derivatives are created when their molecular composition is ‎modified, increasing the probability that they will bind to proteins. Trimethoprim is a ‎bridging bidentate ligand that can bind to metal ions via its amino groups and pyrimidine ‎rings. This review outlines a decade of study on the biological properties of trimethoprim ‎derivatives. Trimethoprim derivatives have been shown to exhibit several biological ‎characteristics throughout the last few decades. With great therapeutic results, it has been ‎utilized to treat a wide range of diseases. Therefore, it is a promising drug with a lot of ‎scope for study. ‎

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Frontiers in Scientific Research and Technology

Articles in Press, Accepted Manuscript
Available Online from 24 February 2025

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